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Donor T-cell alloreactivity against host thymic epithelium limits T-cell development after bone marrow transplantation.

Abstract:

Acute graft-versus-host disease (aGVHD) impairs thymus-dependent T-cell regeneration in recipients of allogeneic bone marrow transplants through yet to be defined mechanisms. Here, we demonstrate in mice that MHC-mismatched donor T cells home into the thymus of unconditioned recipients. There, activated donor T cells secrete IFN-gamma, which in turn stimulates the programmed cell death of thymic epithelial cells (TECs). Because TECs themselves are competent and sufficient to prime naive allos...

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Publication status:
Published

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Journal:
Blood
Volume:
109
Issue:
9
Pages:
4080-4088
Publication date:
2007-05-01
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Source identifiers:
309025

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