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Journal article

Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines.

Abstract:

OBJECTIVE: FBXW7 encodes the substrate recognition component of a ubiquitin ligase that degrades targets such as Notch1, c-Jun, c-Myc and cyclin E. FBXW7 mutations occur in several tumour types, including colorectal cancers. The FBXW7 mutation spectrum in cancers is unusual. Some tumours have biallelic loss of function mutations but most have monoallelic missense mutations involving specific arginine residues at β-propellor tips involved in substrate recognition. DESIGN: FBXW7 functional stud...

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Publication status:
Published

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Publisher copy:
10.1136/gutjnl-2013-304719

Authors


Behrens, A More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Journal:
Gut
Volume:
63
Issue:
5
Pages:
792-799
Publication date:
2014-05-05
DOI:
EISSN:
1468-3288
ISSN:
0017-5749
URN:
uuid:b502201f-d853-4435-8c13-7cdaf76aa06d
Source identifiers:
401846
Local pid:
pubs:401846

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