Crystal structure of a human GABAA receptor.

Journal article

Type-A γ-aminobutyric acid receptors (GABAARs) are the principal mediators of rapid inhibitory synaptic transmission in the human brain. A decline in GABAAR signalling triggers hyperactive neurological disorders such as insomnia, anxiety and epilepsy. Here we present the first three-dimensional structure of a GABAAR, the human β3 homopentamer, at 3 Å resolution. This structure reveals architectural elements unique to eukaryotic Cys-loop receptors, explains the mechanistic consequences of mult...

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Authors: Miller, P; Aricescu, A

• Publication status: Published
• Journal: Nature
• Volume: 512
• Issue: 7514
• Pages: 270-275
• Publication date: 2014-08-01
• DOI: 10.1038/nature13293
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Protein Structure, Quaternary; Models, Molecular; Synaptic Transmission; Cell Membrane; Humans; Genetic Predisposition to Disease; GABA-A Receptor Agonists; Protein Structure, Tertiary; Binding Sites; Mutation; Drug Design; Polysaccharides; Benzamidines; Protein Subunits; Conserved Sequence; Receptors, GABA-A; Crystallography, X-Ray; Glycosylation