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Crystal structure of a human GABAA receptor.

Abstract:

Type-A γ-aminobutyric acid receptors (GABAARs) are the principal mediators of rapid inhibitory synaptic transmission in the human brain. A decline in GABAAR signalling triggers hyperactive neurological disorders such as insomnia, anxiety and epilepsy. Here we present the first three-dimensional structure of a GABAAR, the human β3 homopentamer, at 3 Å resolution. This structure reveals architectural elements unique to eukaryotic Cys-loop receptors, explains the mechanistic consequences of mult...

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Publication status:
Published

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Publisher copy:
10.1038/nature13293

Authors


Miller, PS More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Journal:
Nature
Volume:
512
Issue:
7514
Pages:
270-275
Publication date:
2014-08-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:b4f734f8-ae58-4847-a592-531c28710058
Source identifiers:
469332
Local pid:
pubs:469332

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