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Aβ42/Aβ40 and Aβ42/Aβ38 ratios are associated with measures of gait variability and activities of daily living in mild Alzheimer’s disease: A pilot study

Abstract:

Gait disturbances are some of the earliest changes in dementia and their monitoring presents an opportunity for early diagnosis. The exact relationship between gait and well-established biomarkers of Alzheimer’s disease (AD) remains to be clarified. In this study we compared gait-related measures with cerebrospinal fluid (CSF) markers of AD pathology. We recruited seventeen participants with mild AD in a multi-site study and performed gait assessment as well as lumbar punctures to obtain CSF....

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.3233/JAD-180622

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Zetterberg, H More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
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Medical Research Council More from this funder
National Institute of Health Research More from this funder
Publisher:
IOS Press Publisher's website
Journal:
Journal of Alzheimer's Disease Journal website
Acceptance date:
2018-08-01
DOI:
EISSN:
1875-8908
ISSN:
1387-2877
Pubs id:
pubs:892129
URN:
uri:b4f3fb87-f769-44c6-98c1-0ed0490af822
UUID:
uuid:b4f3fb87-f769-44c6-98c1-0ed0490af822
Local pid:
pubs:892129

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