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Genetic loci influencing kidney function and chronic kidney disease.

Abstract:
Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.
Publication status:
Published

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Publisher copy:
10.1038/ng.566

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Journal:
Nature genetics
Volume:
42
Issue:
5
Pages:
373-375
Publication date:
2010-05-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:b4f0d019-cff0-486c-b025-6c74c89809b8
Source identifiers:
54811
Local pid:
pubs:54811

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