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The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice.

Abstract:

The growth factor progranulin (PGRN) has been implicated in embryonic development, tissue repair, tumorigenesis, and inflammation, but its receptors remain unidentified. We report that PGRN bound directly to tumor necrosis factor receptors (TNFRs) and disturbed the TNFα-TNFR interaction. PGRN-deficient mice were susceptible to collagen-induced arthritis, and administration of PGRN reversed inflammatory arthritis. Atsttrin, an engineered protein composed of three PGRN fragments, exhibited sele...

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Publisher copy:
10.1126/science.1199214

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Journal:
Science (New York, N.Y.)
Volume:
332
Issue:
6028
Pages:
478-484
Publication date:
2011-04-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:b4eea018-e105-4e80-b416-07190e464433
Source identifiers:
426273
Local pid:
pubs:426273

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