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Genome-wide association study of primary open-angle glaucoma in continental and admixed African populations

Abstract:

Primary open angle glaucoma (POAG) is a complex disease with a major genetic contribution. Its prevalence varies greatly among ethnic groups, and is up to five times more frequent in black African populations compared to Europeans. So far, worldwide efforts to elucidate the genetic complexity of POAG in African populations has been limited. We conducted a genome-wide association study in 1113 POAG cases and 1826 controls from Tanzanian, South African and African American study samples. Apart ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1007/s00439-018-1943-7

Authors


Bonnemaijer, PWM More by this author
Iglesias, AI More by this author
Nadkarni, GN More by this author
Sanyiwa, AJ More by this author
Hassan, HG More by this author
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Combined Ophthalmic Research Rotterdam More from this funder
General Dutch Association for Prevention of Blindness More from this funder
Dutch National Foundation for the Blind and Visually impaired More from this funder
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Publisher:
Springer Publisher's website
Journal:
Human Genetics Journal website
Volume:
137
Issue:
10
Pages:
847-862
Publication date:
2018-10-13
Acceptance date:
2018-09-19
DOI:
EISSN:
1432-1203
ISSN:
0340-6717
Pubs id:
pubs:929756
URN:
uri:b4ee90e2-0c2f-406c-88ca-49c5d354463c
UUID:
uuid:b4ee90e2-0c2f-406c-88ca-49c5d354463c
Local pid:
pubs:929756

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