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RAB11FIP5 expression and altered natural killer cell function are associated with induction of HIV broadly neutralizing antibody responses

Abstract:

HIV-1 broadly neutralizing antibodies (bnAbs) are difficult to induce with vaccines but are generated in ∼50% of HIV-1-infected individuals. Understanding the molecular mechanisms of host control of bnAb induction is critical to vaccine design. Here, we performed a transcriptome analysis of blood mononuclear cells from 47 HIV-1-infected individuals who made bnAbs and 46 HIV-1-infected individuals who did not and identified in bnAb individuals upregulation of RAB11FIP5, encoding a Rab effector...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.cell.2018.08.064

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Target Discovery Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Target Discovery Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Target Discovery Institute
Role:
Author
ORCID:
0000-0002-3877-9780
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Grant:
Center for HIV/AIDS Vaccine Immunology-Immunogen Discovery (CHAVI-ID; UMI-AI100645)
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Grant:
MR/K012037 and MR/M008614
Publisher:
Cell Press Publisher's website
Journal:
Cell Journal website
Volume:
175
Issue:
2
Pages:
387-399.e17
Publication date:
2018-09-27
Acceptance date:
2018-08-29
DOI:
ISSN:
0092-8674
Pubs id:
pubs:911164
URN:
uri:b4e911c7-7fac-474c-a66c-92eae94a0be9
UUID:
uuid:b4e911c7-7fac-474c-a66c-92eae94a0be9
Local pid:
pubs:911164

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