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Modulation of interleukin 1 beta gene expression using antisense phosphorothioate oligonucleotides.

Abstract:

The production of interleukin 1 beta (IL1 beta) in lipopolysaccharide (LPS) stimulated monocytes was inhibited by 98% using antisense phosphorothioate oligonucleotides complementary to the 5' untranslated and exon 6 regions of IL1 beta mRNA. A sense phosphorothioate oligonucleotide failed to inhibit IL1 beta production. The inhibition of IL1 beta synthesis was not due to reduced cell viability and [35S]methionine incorporation showed that it could not be accounted for by an overall inhibition...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
Lymphokine research
Volume:
9
Issue:
1
Pages:
35-42
Publication date:
1990
ISSN:
0277-6766
URN:
uuid:b4ceebd2-24df-457d-a511-fcaa7023d41b
Source identifiers:
400099
Local pid:
pubs:400099

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