Journal article
Global survey of the immunomodulatory potential of common drugs.
- Abstract:
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Small molecule drugs may complement antibody-based therapies in an immune-oncology setting, yet systematic methods for the identification and characterization of the immunomodulatory properties of these entities are lacking. We surveyed the immumomodulatory potential of 1,402 small chemical molecules as defined by their ability to alter the cell-cell interactions among peripheral mononuclear leukocytes ex vivo, using automated microscopy and population-wide single-cell image analysis. Surpris...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 22.0MB)
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- Publisher copy:
- 10.1038/nchembio.2360
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Authors
Funding
Torsten and Ragnar Söderberg Foundation
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Knut and Alice Wallenberg Foundation
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Marie-Sklodowska Curie Action
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Chemical Biology Journal website
- Volume:
- 13
- Pages:
- 681–690
- Publication date:
- 2017-04-01
- Acceptance date:
- 2017-01-17
- DOI:
- EISSN:
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1552-4469
- ISSN:
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1552-4469 and 1552-4450
- Source identifiers:
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691161
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:691161
- UUID:
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uuid:b4ae43d2-743e-4281-9030-447a6dc569f2
- Local pid:
- pubs:691161
- Deposit date:
- 2017-04-26
Terms of use
- Copyright holder:
- Nature America, Inc
- Copyright date:
- 2017
- Notes:
- © 2017 Nature America, Inc., part of Springer Nature. All rights reserved.
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