- Abstract:
-
Small molecule drugs may complement antibody-based therapies in an immune-oncology setting, yet systematic methods for the identification and characterization of the immunomodulatory properties of these entities are lacking. We surveyed the immumomodulatory potential of 1,402 small chemical molecules as defined by their ability to alter the cell-cell interactions among peripheral mononuclear leukocytes ex vivo, using automated microscopy and population-wide single-cell image analysis. Surpris...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
- Files:
-
-
(pdf, 22.0mb)
-
- Publisher copy:
- 10.1038/nchembio.2360
-
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- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Chemical Biology Journal website
- Volume:
- 13
- Pages:
- 681–690
- Publication date:
- 2017-04-05
- Acceptance date:
- 2017-01-17
- DOI:
- EISSN:
-
1552-4469
- ISSN:
-
1552-4469 and 1552-4450
- Pubs id:
-
pubs:691161
- URN:
-
uri:b4ae43d2-743e-4281-9030-447a6dc569f2
- UUID:
-
uuid:b4ae43d2-743e-4281-9030-447a6dc569f2
- Local pid:
- pubs:691161
- Language:
- English
- Keywords:
- Copyright holder:
- Nature America, Inc
- Copyright date:
- 2017
- Notes:
- © 2017 Nature America, Inc., part of Springer Nature. All rights reserved.
Journal article
Global survey of the immunomodulatory potential of common drugs.
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European Research Council
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Austrian Federal Ministry of Science, Research, and Economy
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Austrian National Foundation for Research, Technology, and Development
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Swedish Cancer Society
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