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Journal article

Global survey of the immunomodulatory potential of common drugs.

Abstract:

Small molecule drugs may complement antibody-based therapies in an immune-oncology setting, yet systematic methods for the identification and characterization of the immunomodulatory properties of these entities are lacking. We surveyed the immumomodulatory potential of 1,402 small chemical molecules as defined by their ability to alter the cell-cell interactions among peripheral mononuclear leukocytes ex vivo, using automated microscopy and population-wide single-cell image analysis. Surpris...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/nchembio.2360

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
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Torsten and Ragnar Söderberg Foundation More from this funder
Knut and Alice Wallenberg Foundation More from this funder
Marie-Sklodowska Curie Action More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Chemical Biology Journal website
Volume:
13
Pages:
681–690
Publication date:
2017-04-01
Acceptance date:
2017-01-17
DOI:
EISSN:
1552-4469
ISSN:
1552-4469 and 1552-4450
Source identifiers:
691161
Language:
English
Keywords:
Pubs id:
pubs:691161
UUID:
uuid:b4ae43d2-743e-4281-9030-447a6dc569f2
Local pid:
pubs:691161
Deposit date:
2017-04-26

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