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Global survey of the immunomodulatory potential of common drugs.

Abstract:

Small molecule drugs may complement antibody-based therapies in an immune-oncology setting, yet systematic methods for the identification and characterization of the immunomodulatory properties of these entities are lacking. We surveyed the immumomodulatory potential of 1,402 small chemical molecules as defined by their ability to alter the cell-cell interactions among peripheral mononuclear leukocytes ex vivo, using automated microscopy and population-wide single-cell image analysis. Surpris...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/nchembio.2360

Authors


Vladimer, GI More by this author
Snijder, B More by this author
Bigenzahn, JW More by this author
More by this author
Department:
Oxford, MSD, NDM, Target Discovery Institute
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European Research Council More from this funder
Austrian Federal Ministry of Science, Research, and Economy More from this funder
Austrian National Foundation for Research, Technology, and Development More from this funder
Swedish Cancer Society More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Chemical Biology Journal website
Volume:
13
Pages:
681–690
Publication date:
2017-04-05
Acceptance date:
2017-01-17
DOI:
EISSN:
1552-4469
ISSN:
1552-4469 and 1552-4450
Pubs id:
pubs:691161
URN:
uri:b4ae43d2-743e-4281-9030-447a6dc569f2
UUID:
uuid:b4ae43d2-743e-4281-9030-447a6dc569f2
Local pid:
pubs:691161
Language:
English
Keywords:

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