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Can growth inhibition assays (GIA) predict blood-stage malaria vaccine efficacy?

Abstract:

An effective vaccine against P. falciparum malaria remains a global health priority. Blood-stage vaccines are an important component of this effort, with some indications of recent progress. However only a fraction of potential blood-stage antigens have been tested, highlighting a critical need for efficient down-selection strategies. Functional in vitro assays such as the growth/invasion inhibition assays (GIA) are widely used, but it is unclear whether GIA activity correlates with protectio...

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Publication status:
Published

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Publisher copy:
10.4161/hv.19712

Authors


Duncan, CJ More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
Journal:
Human vaccines and immunotherapeutics
Volume:
8
Issue:
6
Pages:
706-714
Publication date:
2012-06-05
DOI:
EISSN:
2164-554X
ISSN:
2164-5515
URN:
uuid:b4ae422e-db8f-4819-b6c0-0209b7271ebd
Source identifiers:
325186
Local pid:
pubs:325186

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