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Sarcolemmal nNOS anchoring reveals a qualitative difference between dystrophin and utrophin

Abstract:

Duchenne muscular dystrophy (DMD) is a lethal muscle disease caused by dystrophin deficiency. In normal muscle, dystrophin helps maintain sarcolemmal stability. Dystrophin also recruits neuronal nitric oxide synthase (nNOS) to the sarcolemma. Failure to anchor nNOS to the membrane leads to functional ischemia and aggravates muscle disease in DMD. Over the past two decades, a great variety of therapeutic modalities have been explored to treat DMD. A particularly attractive approach is to incre...

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Publisher copy:
10.1242/jcs.064808

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Journal:
Journal of Cell Science
Volume:
123
Issue:
12
Pages:
2008-2013
Publication date:
2010-06-15
DOI:
ISSN:
0021-9533
URN:
uuid:b4a887ba-9685-4558-a75d-c6c57cbc94a2
Source identifiers:
106981
Local pid:
pubs:106981
Language:
English
Keywords:

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