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Journal article

DNase I-hypersensitive exons colocalize with promoters and distal regulatory elements.

Abstract:

The precise splicing of genes confers an enormous transcriptional complexity to the human genome. The majority of gene splicing occurs cotranscriptionally, permitting epigenetic modifications to affect splicing outcomes. Here we show that select exonic regions are demarcated within the three-dimensional structure of the human genome. We identify a subset of exons that exhibit DNase I hypersensitivity and are accompanied by 'phantom' signals in chromatin immunoprecipitation and sequencing (ChI...

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Publication status:
Published

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Publisher copy:
10.1038/ng.2677

Authors


Mercer, TR More by this author
Edwards, SL More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Journal:
Nature genetics
Volume:
45
Issue:
8
Pages:
852-859
Publication date:
2013-08-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:b4a7c93d-7144-447e-9cf0-f4546995349c
Source identifiers:
482394
Local pid:
pubs:482394

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