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The influence of haemoglobin and iron on in vitro mycobacterial growth inhibition assays

Abstract:

The current vaccine against tuberculosis, live attenuated Mycobacterium bovis BCG, has variable efficacy, but development of an effective alternative is severely hampered by the lack of an immune correlate of protection. There has been a recent resurgence of interest in functional in vitro mycobacterial growth inhibition assays (MGIAs), which provide a measure of a range of different immune mechanisms and their interactions. We identified a positive correlation between mean corpuscular haemog...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/srep43478

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Department:
Oxford, MSD, NDM, Jenner Institute
Role:
Author
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Department:
Oxford, MSD, NDM, Jenner Institute
Role:
Author
More by this author
Department:
Oxford, MSD, NDM, Jenner Institute
Role:
Author
More by this author
Department:
Oxford, MSD, NDM, Jenner Institute
Role:
Author
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Funding agency for:
Mcshane, H
Universities Federation for Animal Welfare More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Pages:
43478
Publication date:
2017-03-03
Acceptance date:
2017-01-24
DOI:
ISSN:
2045-2322
Pubs id:
pubs:675622
URN:
uri:b4a54acc-8d4d-454a-842f-bed3edb0ddb2
UUID:
uuid:b4a54acc-8d4d-454a-842f-bed3edb0ddb2
Local pid:
pubs:675622

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