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Immune escape variants of H9N2 influenza viruses containing deletions at the hemagglutinin receptor binding site retain fitness in vivo and display enhanced zoonotic characteristics

Abstract:

H9N2 avian influenza viruses are enzootic in poultry across Asia and North Africa, where they pose a threat to human health as both zoonotic agents and potential pandemic candidates. Poultry vaccination against H9N2 viruses has been employed in many regions; however, vaccine effectiveness is frequently compromised due to antigenic drift arising from amino acid substitutions in the major influenza virus antigen hemagglutinin (HA). Using selection with HA-specific monoclonal antibodies, we prev...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/jvi.00218-17

Authors


Peacock, TP More by this author
Benton, DJ More by this author
Sadeyen, J-R More by this author
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Contributors

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Grant:
BB/L018853/1; BBS/E/I/00001759; BBS/E/I/00001708
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Grant:
U117585868; U117512723; U117570592
Publisher:
American Society for Microbiology Publisher's website
Journal:
Journal of Virology Journal website
Volume:
91
Issue:
14
Pages:
e00218-17
Publication date:
2017-05-03
Acceptance date:
2017-04-20
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Pubs id:
pubs:695846
URN:
uri:b4a1479d-4965-4b7c-a31d-f8b7ec04bf86
UUID:
uuid:b4a1479d-4965-4b7c-a31d-f8b7ec04bf86
Local pid:
pubs:695846

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