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Journal article

Effect of membrane filtration of antimalarial drug solutions on in vitro activity against Plasmodium falciparum.

Abstract:

Antimalarial activities of chloroquine, mefloquine, amodiaquine, and quinine in vitro against Plasmodium falciparum were diminished as a consequence of membrane filtration. Filtered drug solutions gave ID(50) values up to 25-fold greater than those of non-filtered (ethanol-sterilized) drug solutions. Loss of activity by filtration was overcome by increasing the drug concentration prior to filtration. Water solutions filtered through Millex-GS filter units consistently showed an absorbance max...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
Journal:
Bulletin of the World Health Organization
Volume:
62
Issue:
3
Pages:
439-444
Publication date:
1984-01-01
EISSN:
1564-0604
ISSN:
0042-9686
Source identifiers:
81846
Language:
English
Keywords:
Pubs id:
pubs:81846
UUID:
uuid:b483f55a-c905-435d-922d-88847865bc50
Local pid:
pubs:81846
Deposit date:
2012-12-19

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