Journal article
A splicing silencer that regulates smooth muscle specific alternative splicing is active in multiple cell types.
- Abstract:
-
Alternative splicing of alpha-tropomyosin (alpha-TM) involves mutually exclusive selection of exons 2 and 3. Selection of exon 2 in smooth muscle (SM) cells is due to inhibition of exon 3, which requires both binding sites for polypyrimidine tract-binding protein as well as UGC (or CUG) repeat elements on both sides of exon 3. Point mutations or substitutions of the UGC-containing upstream regulatory element (URE) with other UGC elements disrupted the alpha-TM splicing pattern in transfected ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1093/nar/gkf480
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Authors
Bibliographic Details
- Journal:
- Nucleic acids research
- Volume:
- 30
- Issue:
- 16
- Pages:
- 3548-3557
- Publication date:
- 2002-08-01
- DOI:
- EISSN:
-
1362-4962
- ISSN:
-
0305-1048
- Source identifiers:
-
55268
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:55268
- UUID:
-
uuid:b481f1a6-834b-4eee-8fa0-9bbade161af6
- Local pid:
- pubs:55268
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2002
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