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Journal article

A splicing silencer that regulates smooth muscle specific alternative splicing is active in multiple cell types.

Abstract:

Alternative splicing of alpha-tropomyosin (alpha-TM) involves mutually exclusive selection of exons 2 and 3. Selection of exon 2 in smooth muscle (SM) cells is due to inhibition of exon 3, which requires both binding sites for polypyrimidine tract-binding protein as well as UGC (or CUG) repeat elements on both sides of exon 3. Point mutations or substitutions of the UGC-containing upstream regulatory element (URE) with other UGC elements disrupted the alpha-TM splicing pattern in transfected ...

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Publication status:
Published

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Publisher copy:
10.1093/nar/gkf480

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Nucleic acids research
Volume:
30
Issue:
16
Pages:
3548-3557
Publication date:
2002-08-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:b481f1a6-834b-4eee-8fa0-9bbade161af6
Source identifiers:
55268
Local pid:
pubs:55268

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