Journal article icon

Journal article

Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor.

Abstract:
Substrate specificity: Biochemical and crystallographic analyses reveal the hypoxia-inducible factor hydroxylase (FIH) as being promiscuous with respect to the residues that it can hydroxylate in β-position, which in addition to Asn, Asp, and His include Leu and Ser residues. The Ser substrate is oxidized to an epimeric β-geminal diol product (see picture). Copyright © 2013 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim.
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1002/anie.201208046

Authors


Chowdhury, R More by this author
Scotti, JS More by this author
Expand authors...
Journal:
Angewandte Chemie (International ed. in English)
Volume:
52
Issue:
6
Pages:
1700-1704
Publication date:
2013-02-05
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
URN:
uuid:b47f0d6c-c29a-4ac5-a4cb-c3ba5d306c3d
Source identifiers:
374218
Local pid:
pubs:374218

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP