- Abstract:
-
TLR signal via Toll-IL-1R (TIR) homology domain-containing adaptor proteins. One of these adaptors, Toll-IL-1R domain-containing adaptor inducing IFN-beta-related adaptor molecule (TRAM), has been shown to be essential for TLR4 signaling in TRAM(-/-) mice and cell lines. Previously, we showed that MyD88 or Mal dominant-negative constructs did not inhibit LPS induction of cytokines in primary human M-CSF-derived macrophages. A possible explanation was redundancy of the adaptors during LPS sign...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.4049/jimmunol.178.4.2148
-
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- Journal:
- Journal of immunology (Baltimore, Md. : 1950)
- Volume:
- 178
- Issue:
- 4
- Pages:
- 2148-2154
- Publication date:
- 2007-02-05
- DOI:
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- URN:
-
uuid:b47366ee-de57-4a04-8449-d6cf0c5903cc
- Source identifiers:
-
224740
- Local pid:
- pubs:224740
- Language:
- English
- Keywords:
- Copyright date:
- 2007
Journal article
Selective use of TRAM in lipopolysaccharide (LPS) and lipoteichoic acid (LTA) induced NF-kappaB activation and cytokine production in primary human cells: TRAM is an adaptor for LPS and LTA signaling.
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