Thesis
An investigation of enzyme mechanisms using substrate analogues
- Abstract:
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The synthesis of several fluorinated analogues of thiamine and precursors has been undertaken, all of which exhibit weak activity against E.Coli. A route to 3-fluoro-(R)-alanine has been explored.
The first synthesis of the enantiomeric fluorosuccinic acids has been accomplished, and a stereochemical analysis has shown that synthesis via esterified malate precursors using diethylamino- sulphurtrifluoride gives inversion of configuration, whereas ...
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Bibliographic Details
- Publication date:
- 1980
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
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English
- Subjects:
- UUID:
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uuid:b45f624d-daba-42f5-ab48-772345883e08
- Local pid:
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td:602800730
- Source identifiers:
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602800730
- Deposit date:
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2013-01-18
Terms of use
- Copyright holder:
- Potter, B
- Copyright date:
- 1980
- Notes:
- The digital copy of this thesis has been made available thanks to the generosity of Dr Leonard Polonsky
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