Journal article icon

Journal article

Site-selective chemical protein glycosylation protects from autolysis and proteolytic degradation.

Abstract:

Glycosylation is often cited as having a stabilizing effect upon proteins with respect to proteolysis, thermolysis and other forms of degradation. We present here a model study on an autolytic protease that has been chemically glycosylated to produce single glycoforms. The resulting glycosylated enzymes are more stable with respect to their own autolytic degradation and that by other proteases. Kinetic parameters for protease activity with respect to the degradation of small-molecule amide su...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Russell, D More by this author
Oldham, NJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
Carbohydrate research
Volume:
344
Issue:
12
Pages:
1508-1514
Publication date:
2009-08-05
DOI:
EISSN:
1873-426X
ISSN:
0008-6215
URN:
uuid:b45f09b1-b852-42c5-95cb-190bbf7f2c85
Source identifiers:
34800
Local pid:
pubs:34800

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP