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Regulation of dense-core granule replenishment by autocrine BMP signalling in Drosophila secondary cells

Abstract:

Regulated secretion by glands and neurons involves release of signalling molecules and enzymes selectively concentrated in dense-core granules (DCGs). Although we understand how many secretagogues stimulate DCG release, how DCG biogenesis is then accelerated to replenish the DCG pool remains poorly characterised. Here we demonstrate that each prostate-like secondary cell (SC) in the paired adult Drosophila melanogaster male accessory glands contains approximately ten large DCGs, which are loa...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pgen.1006366

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Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Publisher:
Public Library of Sciences Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
12
Issue:
10
Pages:
e1006366
Publication date:
2016-10-05
Acceptance date:
2016-09-21
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Pubs id:
pubs:646123
URN:
uri:b45b68e1-0c41-4ab2-8dc6-21903c3cf941
UUID:
uuid:b45b68e1-0c41-4ab2-8dc6-21903c3cf941
Local pid:
pubs:646123

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