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Journal article

SMG-1 and mTORC1 act antagonistically to regulate response to injury and growth in planarians

Abstract:

Planarian flatworms are able to both regenerate their whole bodies and continuously adapt their size to nutrient status. Tight control of stem cell proliferation and differentiation during these processes is the key feature of planarian biology. Here we show that the planarian homolog of the phosphoinositide 3-kinase-related kinase (PIKK) family member SMG-1 and mTOR complex 1 components are required for this tight control. Loss of smg-1 results in a hyper-responsiveness to injury and growth ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1371/journal.pgen.1002619

Authors


Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
8
Issue:
3
Pages:
e1002619
Publication date:
2012-03-29
Acceptance date:
2012-02-08
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Source identifiers:
323366
Language:
English
Keywords:
Pubs id:
pubs:323366
UUID:
uuid:b4506cf3-628f-4a8d-95cd-d03e2e227a81
Local pid:
pubs:323366
Deposit date:
2013-11-16

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