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Journal article

Posttranslational modifications of p27kip1 determine its binding specificity to different cyclins and cyclin-dependent kinases in vivo.

Abstract:

Using 2-dimensional gel electrophoresis (2D-gel) analysis, we show here that cell-cycle entry is associated with a significant increase in p27(kip1) phosphorylation in human primary B cells. A similar pattern of increase in p27(kip1) phosphorylation was also seen in 2 fast-growing tumor cell lines, Burkitt lymphoma cell line BL40 and breast carcinoma cell line Cal51, where inactive p27(kip1) is expressed at high levels. Detailed analysis revealed for the first time that different cyclins and ...

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Publication status:
Published

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Publisher copy:
10.1182/blood-2003-07-2558

Authors


Bergamaschi, D More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Oxford Ludwig Institute
Journal:
Blood
Volume:
105
Issue:
9
Pages:
3691-3698
Publication date:
2005-05-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:b449da37-5ee4-4de7-a99a-85f6dfd8c837
Source identifiers:
83972
Local pid:
pubs:83972

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