Tolerance in the mouse to major histocompatibility complex-mismatched heart allografts, and to rat heart xenografts, using monoclonal antibodies to CD4 and CD8.

Journal article

Mice given a single short course of anti-CD4 and anti-CD8 monoclonal antibodies (mAb) became tolerant of major histocompatibility complex (MHC)-incompatible vascularized heart allografts in a donor- and organ-specific manner. T cell depletion was not important, as blocking antibodies were equally effective. Anti-CD4 antibody therapy alone was sufficient to establish tolerance. Anti-CD8 mAb therapy alone was associated with poor recipient survival, although survivors were rendered tolerant. A ...

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Authors: Chen, Z; Cobbold, S; Metcalfe, S; Waldmann, H

• Publication status: Published
• Journal: European journal of immunology
• Volume: 22
• Issue: 3
• Pages: 805-810
• Publication date: 1992-03-01
• DOI: 10.1002/eji.1830220326
• EISSN: 1521-4141
• ISSN: 0014-2980
• Language: English
• Keywords: Antigens, CD4; Skin Transplantation; Heart Transplantation; Histocompatibility Antigens; Immune Tolerance; Antibodies, Monoclonal; Graft Survival; Rats; Male; Transplantation, Homologous; Mice, Inbred Strains; Transplantation, Heterologous; Mice; Antigens, CD8; T-Lymphocytes; Animals