Journal article icon

Journal article

Tolerance in the mouse to major histocompatibility complex-mismatched heart allografts, and to rat heart xenografts, using monoclonal antibodies to CD4 and CD8.

Abstract:

Mice given a single short course of anti-CD4 and anti-CD8 monoclonal antibodies (mAb) became tolerant of major histocompatibility complex (MHC)-incompatible vascularized heart allografts in a donor- and organ-specific manner. T cell depletion was not important, as blocking antibodies were equally effective. Anti-CD4 antibody therapy alone was sufficient to establish tolerance. Anti-CD8 mAb therapy alone was associated with poor recipient survival, although survivors were rendered tolerant. A ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1002/eji.1830220326

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
European journal of immunology
Volume:
22
Issue:
3
Pages:
805-810
Publication date:
1992-03-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:b432a0a0-1847-47b8-9d1c-4460521e929c
Source identifiers:
10691
Local pid:
pubs:10691

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP