The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes.

Journal article

Genetic association studies are viewed as problematic and plagued by irreproducibility. Many associations have been reported for type 2 diabetes, but none have been confirmed in multiple samples and with comprehensive controls. We evaluated 16 published genetic associations to type 2 diabetes and related sub-phenotypes using a family-based design to control for population stratification, and replication samples to increase power. We were able to confirm only one association, that of the commo...

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Authors: Altshuler, D; Hirschhorn, J; Klannemark, M; Lindgren, C; Vohl, M

• Publication status: Published
• Journal: Nature genetics
• Volume: 26
• Issue: 1
• Pages: 76-80
• Publication date: 2000-09-01
• DOI: 10.1038/79216
• EISSN: 1546-1718
• ISSN: 1061-4036
• Language: English
• Keywords: Risk Factors; Linkage Disequilibrium; Receptors, Cytoplasmic and Nuclear; Polymorphism, Genetic; Female; Mothers; Blood Glucose; Age of Onset; Adult; Middle Aged; Diabetes Mellitus, Type 2; Transcription Factors; Family Health; Alanine; Alleles; Models, Genetic; Phenotype; Aged; Humans; Cholesterol; Fathers; Blood Pressure; Proline; Genotype; Male; Body Mass Index; Lipoproteins, HDL