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Journal article

IFN-gamma exposes a cryptic cytotoxic T lymphocyte epitope in HIV-1 reverse transcriptase.

Abstract:

The proteasome, an essential component of the ATP-dependent proteolytic pathway in eukaryotic cells, is responsible for the degradation of most cellular proteins and is believed to be the main source of MHC class I-restricted antigenic peptides for presentation to CTL. Inhibition of the proteasome by lactacystin or various peptide aldehydes can result in defective Ag presentation, and the pivotal role of the proteasome in Ag processing has become generally accepted. However, recent reports ha...

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Publication status:
Published

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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
162
Issue:
12
Pages:
7075-7079
Publication date:
1999-06-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:b41d147c-1a22-458c-8787-2bb42a9b16c1
Source identifiers:
10404
Local pid:
pubs:10404

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