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Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells.

Abstract:

PGD2, produced by mast cells, has been detected in high concentrations at sites of allergic inflammation. It can stimulate vascular and other inflammatory responses by interaction with D prostanoid receptor (DP) and chemoattractant receptor-like molecule expressed on Th2 cells (CRTH2) receptors. A significant role for PGD2 in mediating allergic responses has been suggested based on the observation that enhanced eosinophilic lung inflammation and cytokine production is apparent in the allergen...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Wettey, FR More by this author
Townsend, E More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
175
Issue:
10
Pages:
6531-6536
Publication date:
2005-11-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:b414c655-3bc2-4618-84a5-2b58814b175b
Source identifiers:
111580
Local pid:
pubs:111580

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