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Promises and challenges of adoptive T-cell therapies for solid tumours

Abstract:

Cancer is a leading cause of death worldwide and, despite new targeted therapies and immunotherapies, many patients with advanced-stage- or high-risk cancers still die, owing to metastatic disease. Adoptive T-cell therapy, involving the autologous or allogeneic transplant of tumour-infiltrating lymphocytes or genetically modified T cells expressing novel T-cell receptors or chimeric antigen receptors, has shown promise in the treatment of cancer patients, leading to durable responses and, in ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41416-021-01353-6

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
ORCID:
0000-0002-4780-3199
Publisher:
Springer Nature
Journal:
British Journal of Cancer More from this journal
Volume:
124
Issue:
11
Pages:
1759-1776
Publication date:
2021-03-29
Acceptance date:
2021-01-13
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
Language:
English
Keywords:
Pubs id:
1158724
Local pid:
pubs:1158724
Deposit date:
2021-01-26

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