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Deep-tissue multi-photon fluorescence lifetime microscopy for intravital imaging of protein-protein interactions

Abstract:

Fluorescent lifetime imaging microscopy (FLIM) has proven to be a valuable tool in beating the Rayleigh criterion for light microscopy by measuring Förster resonance energy transfer (FRET) between two fluorophores. Applying multiphoton FLIM, we previously showed in a human breast cancer cell line that recycling of a membrane receptorgreen fluorescent protein fusion is enhanced concomitantly with the formation of a receptor:protein kinase C a complex in the endosomal compartment. We have exten...

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Publication status:
Published

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Publisher copy:
10.1117/12.817129

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
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Journal:
MULTIPHOTON MICROSCOPY IN THE BIOMEDICAL SCIENCES IX
Volume:
7183
Publication date:
2009-01-01
DOI:
ISSN:
0277-786X
URN:
uuid:b403f554-710b-4e84-9348-ec8c52e0a875
Source identifiers:
95003
Local pid:
pubs:95003

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