- Abstract:
-
Toll-like receptors (TLRs) trigger intestinal inflammation when the epithelial barrier is breached by physical trauma or pathogenic microbes. Although it has been shown that TLR-mediated signals are ultimately protective in models of acute intestinal inflammation [such as dextran sulfate sodium (DSS)-induced colitis], it is less clear which cells mediate protection. Here we demonstrate that TLR signaling in the nonhematopoietic compartment confers protection in acute DSS-induced colitis. Epit...
Expand abstract - Publisher copy:
- 10.1073/pnas.1014669107
-
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- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 107
- Issue:
- 46
- Pages:
- 19967-19972
- Publication date:
- 2010-11-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:b3eb4d2d-9e07-4d18-a4ad-2c025d473100
- Source identifiers:
-
418823
- Local pid:
- pubs:418823
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands.
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