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MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands.

Abstract:

Toll-like receptors (TLRs) trigger intestinal inflammation when the epithelial barrier is breached by physical trauma or pathogenic microbes. Although it has been shown that TLR-mediated signals are ultimately protective in models of acute intestinal inflammation [such as dextran sulfate sodium (DSS)-induced colitis], it is less clear which cells mediate protection. Here we demonstrate that TLR signaling in the nonhematopoietic compartment confers protection in acute DSS-induced colitis. Epit...

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Publisher copy:
10.1073/pnas.1014669107

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
107
Issue:
46
Pages:
19967-19972
Publication date:
2010-11-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:b3eb4d2d-9e07-4d18-a4ad-2c025d473100
Source identifiers:
418823
Local pid:
pubs:418823

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