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Reduced helminth burden increases allergen skin sensitization but not clinical allergy: a randomized, double-blind, placebo-controlled trial in Vietnam.

Abstract:

BACKGROUND: Observational evidence suggests that infection with helminths protects against allergic disease and allergen skin sensitization. It is postulated that such effects are mediated by helminth-induced cytokine responses, in particular IL-10. OBJECTIVE: We tested this hypothesis in a rural area of central Vietnam where hookworm infection is endemic. METHODS: One thousand five hundred and sixty-six schoolchildren aged 6-17 were randomly allocated to receive either anti-helminthic thera...

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Publication status:
Published

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Authors


Quinnell, RJ More by this author
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Journal:
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Volume:
40
Issue:
1
Pages:
131-142
Publication date:
2010-01-05
DOI:
EISSN:
1365-2222
ISSN:
0954-7894
URN:
uuid:b3e3f946-bbee-4c73-b7b5-fc53b00173ac
Source identifiers:
41484
Local pid:
pubs:41484

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