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Polyspecific intravenous immunoglobulin in clindamycin-treated patients with streptococcal toxic shock syndrome: a systematic review and meta-analysis

Abstract:
We evaluated the effect of adjunctive intravenous immunoglobulin (IVIG) on mortality in clindamycin-treated streptococcal toxic shock syndrome patients using a meta-analysis. In association with IVIG, mortality fell from 33.7% to 15.7% (risk ratio 0.46, 95% confidence intervals 0.26-0.83, p=0.010) with remarkable consistency across the single randomised and four non-randomised studies.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/cid/ciy401

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
ORCID:
0000-0002-1163-8654
Norrby-Teglund, A More by this author
Sriskandan. S More by this author
Publisher:
Oxford University Press Publisher's website
Publication date:
2018-05-17
Acceptance date:
2018-04-08
DOI:
Pubs id:
pubs:853500
URN:
uri:b3d48e6e-c59b-412f-8c6f-87ef0b68c358
UUID:
uuid:b3d48e6e-c59b-412f-8c6f-87ef0b68c358
Local pid:
pubs:853500

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