Zolmitriptan-induced growth hormone release in humans: mediation by 5-HT1D receptors?

Journal article

RATIONALE: Effective neuroendocrine probes of 5-HT1B and 5-HT1D receptor function may facilitate investigation of the role of these receptor subtypes in the pathophysiology of depression and the mode of action of antidepressant medication. OBJECTIVE: To investigate the neuroendocrine profile of the 5-HT1B/1D receptor agonist, zolmitriptan, in healthy volunteers. METHODS: Twelve subjects entered a double-blind, placebo-controlled, cross-over design study of zolmitriptan (5 mg orally). Blood s...

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Authors: Whale, R; Bhagwagar, Z; Cowen, P

• Publication status: Published
• Journal: Psychopharmacology
• Volume: 145
• Issue: 2
• Pages: 223-226
• Publication date: 1999-07-01
• DOI: 10.1007/s002130051052
• EISSN: 1432-2072
• ISSN: 0033-3158
• Language: English
• Keywords: Adolescent; Male; Double-Blind Method; Female; Cross-Over Studies; Tryptamines; Oxazolidinones; Sumatriptan; Middle Aged; Receptors, Serotonin; Human Growth Hormone; Serotonin Receptor Agonists; Oxazoles; Humans; Adult; Receptor, Serotonin, 5-HT1D