Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis.

Journal article

Many human cancer susceptibility genes have been successfully mapped by genetic linkage studies. One that has so far eluded researchers is that for Peutz-Jeghers (P-J) syndrome, a condition characterized by intestinal hamartomatous polyposis and melanin spots of the lips, buccal mucosa and digits. A dramatically elevated risk of malignancy has also been documented. Gastrointestinal tumours as well as cancers of the breast, ovary, testis and uterine cervix appear to be overrepresented in famil...

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Authors: Hemminki, A; Tomlinson, I; Markie, D; Järvinen, H; Sistonen, P

• Publication status: Published
• Journal: Nature genetics
• Volume: 15
• Issue: 1
• Pages: 87-90
• Publication date: 1997-01-01
• DOI: 10.1038/ng0197-87
• EISSN: 1546-1718
• ISSN: 1061-4036
• Language: English
• Keywords: Gene Deletion; Humans; Genetic Predisposition to Disease; Genetic Linkage; Karyotyping; Nucleic Acid Hybridization; Adenocarcinoma; Peutz-Jeghers Syndrome; Adult; Heterozygote; Chromosomes, Human, Pair 19; Female; Male