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Journal article

Screening and functional profiling of small-molecule HIV-1 entry and fusion inhibitors

Abstract:

HIV-1 entry and fusion with target cells is an important target for antiviral therapy. However, a few currently approved treatments are not effective as monotherapy due to the emergence of drug resistance. This consideration has fueled efforts to develop new bioavailable inhibitors targeting different steps of the HIV-1 entry process. Here, a high-throughput screen was performed of a large library of 100,000 small molecules for HIV-1 entry/fusion inhibitors, using a direct virus–cell fusion a...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1089/adt.2017.777

Authors


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Publisher:
Mary Ann Liebert Inc. Publisher's website
Journal:
ASSAY and Drug Development Technologies Journal website
Issue:
2
Publication date:
2017-03-01
Acceptance date:
2017-02-01
DOI:
ISSN:
1540-658X
Pubs id:
pubs:858858
URN:
uri:b3b671a7-5a19-42ad-8c11-b7d7133e78aa
UUID:
uuid:b3b671a7-5a19-42ad-8c11-b7d7133e78aa
Local pid:
pubs:858858

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