- Abstract:
-
Protein kinases play a pivotal role in cell signaling, and dysregulation of many kinases has been linked to disease development. A large number of kinase inhibitors are therefore currently under investigation in clinical trials, and so far seven inhibitors have been approved as anti-cancer drugs. In addition, kinase inhibitors are widely used as specific probes to study cell signaling, but systematic studies describing selectivity of these reagents across a panel of diverse kinases are largel...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1073/pnas.0708800104
-
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- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 104
- Issue:
- 51
- Pages:
- 20523-20528
- Publication date:
- 2007-12-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:b3b31215-a1ef-4bd5-bf8d-8de8768814f8
- Source identifiers:
-
34076
- Local pid:
- pubs:34076
- Copyright date:
- 2007
Journal article
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
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