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A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Abstract:

Protein kinases play a pivotal role in cell signaling, and dysregulation of many kinases has been linked to disease development. A large number of kinase inhibitors are therefore currently under investigation in clinical trials, and so far seven inhibitors have been approved as anti-cancer drugs. In addition, kinase inhibitors are widely used as specific probes to study cell signaling, but systematic studies describing selectivity of these reagents across a panel of diverse kinases are largel...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0708800104

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Role:
Author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
104
Issue:
51
Pages:
20523-20528
Publication date:
2007-12-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:b3b31215-a1ef-4bd5-bf8d-8de8768814f8
Source identifiers:
34076
Local pid:
pubs:34076

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