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Blood pressure-lowering treatment strategies based on cardiovascular risk versus blood pressure: A meta-analysis of individual participant data

Abstract:
Background: Clinical practice guidelines have traditionally recommended blood pressure treatment based primarily on blood pressure thresholds. In contrast, using predicted cardiovascular risk has been advocated as a more effective strategy to guide treatment decisions for cardiovascular disease (CVD) prevention. We aimed to compare outcomes from a blood pressure-lowering treatment strategy based on predicted cardiovascular risk with one based on systolic blood pressure (SBP) ... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pmed.1002538

Authors


Karmali, KN More by this author
Lloyd-Jones, DM More by this author
van der Leeuw, J More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
George Institute for Global Health
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National Institute for Health Research More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Medicine Journal website
Volume:
15
Issue:
3
Pages:
Article: e1002538
Publication date:
2018-03-20
Acceptance date:
2018-01-20
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
Pubs id:
pubs:822221
URN:
uri:b3b109d2-90f7-4225-9977-c45901d08a9f
UUID:
uuid:b3b109d2-90f7-4225-9977-c45901d08a9f
Local pid:
pubs:822221
Paper number:
3

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