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Persistent reduction in brain serotonin1A receptor binding in recovered depressed men measured by positron emission tomography with [11C]WAY-100635.

Abstract:

Positron emission tomography (PET) studies with the selective 5-HT(1A) receptor ligand, [(11)C]WAY-100635, have indicated that the binding potential (BP) of brain 5-HT(1A) receptors is lowered in unmedicated subjects with acute major depression. However, it is unclear if these changes persist after recovery from depression. To resolve this issue, we used [(11)C]WAY-100635 in conjunction with PET imaging to compare 5-HT(1A) BP in 18 healthy controls and 14 male subjects with recurrent major de...

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Publication status:
Published

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Publisher copy:
10.1038/sj.mp.4001401

Authors


Journal:
Molecular psychiatry
Volume:
9
Issue:
4
Pages:
386-392
Publication date:
2004-04-05
DOI:
EISSN:
1476-5578
ISSN:
1359-4184
URN:
uuid:b3a687de-a58b-43fa-b915-8a5811441ae0
Source identifiers:
185798
Local pid:
pubs:185798

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