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PARP regulates nonhomologous end joining through retention of Ku at double-strand breaks.

Abstract:

Poly adenosine diphosphate (ADP)-ribosylation (PARylation) by poly ADP-ribose (PAR) polymerases (PARPs) is an early response to DNA double-strand breaks (DSBs). In this paper, we exploit Dictyostelium discoideum to uncover a novel role for PARylation in regulating nonhomologous end joining (NHEJ). PARylation occurred at single-strand breaks, and two PARPs, Adprt1b and Adprt2, were required for resistance to this kind of DNA damage. In contrast, although Adprt1b was dispensable for PARylation ...

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Publication status:
Published

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Publisher copy:
10.1083/jcb.201012132

Authors


Siddaway, R More by this author
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Journal:
The Journal of cell biology
Volume:
194
Issue:
3
Pages:
367-375
Publication date:
2011-08-05
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
URN:
uuid:b39c0a60-4e72-4134-8076-ba32624c8d9b
Source identifiers:
167581
Local pid:
pubs:167581

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