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Molecular changes in synovial fluid following human knee injury are associated with early clinical outcomes

Abstract:

Purpose: We studied whether molecules which were up-regulated within hours of surgical joint destabilisation in the mouse were also elevated in the analogous human setting of acute knee injury, how this molecular response varied between individuals,and whether it related to patient-reported outcomes in the 3 months after injury. Methods: 7 candidate molecules were analysed in blood and synovial fluid (SF) at baseline,14 days and 3 months following baseline visit of 150 participants in the Kn...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.joca.2016.01.068

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Department:
Oxford, MSD, NDORMS
Paterson, E More by this author
Freidin, A More by this author
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Publisher:
Elsevier Inc. Publisher's website
Volume:
24
Issue:
Suppl. 1
Publication date:
2016-03-31
DOI:
ISSN:
1063-4584
Pubs id:
pubs:618751
URN:
uri:b39a624b-f929-43a8-ba23-732b05c99ba1
UUID:
uuid:b39a624b-f929-43a8-ba23-732b05c99ba1
Local pid:
pubs:618751
Keywords:

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