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Delta-like ligand 4-notch blockade and tumor radiation response.

Abstract:

BACKGROUND: The microenvironment plays an important role in regulating tumor response to radiotherapy. Ionizing radiation can disrupt tumor vasculature, and Notch pathway inhibition can interfere with functional angiogenesis. We explored the potential cooperativity between Notch inhibition and ionizing radiation in delaying tumor growth. METHODS: Human colorectal carcinoma LS174T cells, which express the Notch ligand delta-like ligand 4 (DLL4), and human head and neck cancer FaDu cells, whic...

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Publication status:
Published

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Publisher copy:
10.1093/jnci/djr419

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Journal:
Journal of the National Cancer Institute
Volume:
103
Issue:
23
Pages:
1778-1798
Publication date:
2011-12-05
DOI:
EISSN:
1460-2105
ISSN:
0027-8874
URN:
uuid:b39a5367-28de-4463-bfac-bcfb22bcf22e
Source identifiers:
193388
Local pid:
pubs:193388

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