Delta-like ligand 4-notch blockade and tumor radiation response.

Journal article

BACKGROUND: The microenvironment plays an important role in regulating tumor response to radiotherapy. Ionizing radiation can disrupt tumor vasculature, and Notch pathway inhibition can interfere with functional angiogenesis. We explored the potential cooperativity between Notch inhibition and ionizing radiation in delaying tumor growth. METHODS: Human colorectal carcinoma LS174T cells, which express the Notch ligand delta-like ligand 4 (DLL4), and human head and neck cancer FaDu cells, whic...

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Authors: Liu, S; Bham, SA; Fokas, E; Beech, J; Im, J

• Publication status: Published
• Journal: Journal of the National Cancer Institute
• Volume: 103
• Issue: 23
• Pages: 1778-1798
• Publication date: 2011-12-01
• DOI: 10.1093/jnci/djr419
• EISSN: 1460-2105
• ISSN: 0027-8874
• Language: English
• Keywords: Neoplasms; Signal Transduction; Blood Flow Velocity; Humans; Colorectal Neoplasms; Antibodies, Monoclonal; Mice; Carcinoma, Squamous Cell; Hypopharyngeal Neoplasms; Immunohistochemistry; Animals; Receptors, Notch; Amyloid Precursor Protein Secretases; Radiation, Ionizing; Luminescent Measurements; Transplantation, Heterologous; Cell Line, Tumor; Antineoplastic Agents; Dibenzazepines; Necrosis; Mice, Nude; Adenocarcinoma; Combined Modality Therapy; Intercellular Signaling Peptides and Proteins; Ultrasonography, Doppler; Immunoblotting; Neovascularization, Pathologic