- Abstract:
-
BACKGROUND: The microenvironment plays an important role in regulating tumor response to radiotherapy. Ionizing radiation can disrupt tumor vasculature, and Notch pathway inhibition can interfere with functional angiogenesis. We explored the potential cooperativity between Notch inhibition and ionizing radiation in delaying tumor growth. METHODS: Human colorectal carcinoma LS174T cells, which express the Notch ligand delta-like ligand 4 (DLL4), and human head and neck cancer FaDu cells, whic...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1093/jnci/djr419
-
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- Journal:
- Journal of the National Cancer Institute
- Volume:
- 103
- Issue:
- 23
- Pages:
- 1778-1798
- Publication date:
- 2011-12-05
- DOI:
- EISSN:
-
1460-2105
- ISSN:
-
0027-8874
- URN:
-
uuid:b39a5367-28de-4463-bfac-bcfb22bcf22e
- Source identifiers:
-
193388
- Local pid:
- pubs:193388
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
Delta-like ligand 4-notch blockade and tumor radiation response.
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