Journal article
Delta-like ligand 4-notch blockade and tumor radiation response.
- Abstract:
-
BACKGROUND: The microenvironment plays an important role in regulating tumor response to radiotherapy. Ionizing radiation can disrupt tumor vasculature, and Notch pathway inhibition can interfere with functional angiogenesis. We explored the potential cooperativity between Notch inhibition and ionizing radiation in delaying tumor growth. METHODS: Human colorectal carcinoma LS174T cells, which express the Notch ligand delta-like ligand 4 (DLL4), and human head and neck cancer FaDu cells, whic...
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- Publication status:
- Published
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- Publisher copy:
- 10.1093/jnci/djr419
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Authors
Bibliographic Details
- Journal:
- Journal of the National Cancer Institute
- Volume:
- 103
- Issue:
- 23
- Pages:
- 1778-1798
- Publication date:
- 2011-12-05
- DOI:
- EISSN:
-
1460-2105
- ISSN:
-
0027-8874
- URN:
-
uuid:b39a5367-28de-4463-bfac-bcfb22bcf22e
- Source identifiers:
-
193388
- Local pid:
- pubs:193388
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2011
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