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Horizontal DNA transfer mechanisms of bacteria as weapons of intragenomic conflict

Abstract:

Horizontal DNA transfer (HDT) is a pervasive mechanism of diversification in many microbial species, but its primary evolutionary role remains controversial. Much recent research has emphasised the adaptive benefit of acquiring novel DNA, but here we argue instead that intragenomic conflict provides a coherent framework for understanding the evolutionary origins of HDT. To test this hypothesis, we developed a mathematical model of a clonally descended bacterial population undergoing HDT throu...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pbio.1002394

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Department:
Oxford, MSD, NDM, Tropical Medicine, Thailand/Laos MOP
Role:
Author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Biology Journal website
Volume:
14
Issue:
3
Pages:
e1002394
Publication date:
2016-03-02
Acceptance date:
2016-01-29
DOI:
EISSN:
1545-7885
ISSN:
1544-9173
Pubs id:
pubs:609514
URN:
uri:b399ae13-09da-43a9-b72d-8fb5f816a9bf
UUID:
uuid:b399ae13-09da-43a9-b72d-8fb5f816a9bf
Local pid:
pubs:609514
Paper number:
3

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