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In for a penny, in for a pound: methylphenidate reduces the inhibitory effect of high stakes on persistent risky choice.

Abstract:

Methylphenidate (MPH) is a stimulant that increases extracellular levels of dopamine and noradrenaline. It can diminish risky decision-making tendencies in certain clinical populations. MPH is also used, without license, by healthy adults, but the impact on their decision-making is not well established. Previous work has found that dopamine receptor activity of healthy adults can modulate the influence of stake magnitude on decisions to persistently gamble after incurring a loss. In this stud...

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Publication status:
Published

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Journal:
Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
32
Issue:
38
Pages:
13032-13038
Publication date:
2012-09-01
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
Source identifiers:
352491

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