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Selective loss of P2Y2 nucleotide receptor immunoreactivity is associated with Alzheimer's disease neuropathology.

Abstract:

The uridine nucleotide-activated P2Y2, P2Y4 and P2Y6 receptors are widely expressed in the brain and are involved in many CNS processes, including those which malfunction in Alzheimer's disease (AD). However, the status of these receptors in the AD neocortex, as well as their putative roles in the pathogenesis of neuritic plaques and neurofibrillary tangles, remain unclear. In this study, we used immunoblotting to measure P2Y2, P2Y4 and P2Y6 receptors in two regions of the postmortem neocorte...

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Publication status:
Published

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Publisher copy:
10.1007/s00702-008-0067-y

Authors


Kirvell, S More by this author
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Journal:
Journal of neural transmission (Vienna, Austria : 1996)
Volume:
115
Issue:
8
Pages:
1165-1172
Publication date:
2008-08-05
DOI:
EISSN:
1435-1463
ISSN:
0300-9564
URN:
uuid:b37bb4c7-b902-4de2-9c14-cf8b12ec150f
Source identifiers:
243316
Local pid:
pubs:243316

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