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The effect of glibenclamide on insulin secretion at normal glucose concentrations.

Abstract:

AIMS/HYPOTHESIS: The aim of this study was to investigate the incremental and proportional effect of a sulfonylurea on insulin secretion rates at low, elevated and high blood glucose, using parallel groups with ascending or descending glucose steps to minimise potential biases of a single stepped clamp order. METHODS: Following 14 days on placebo or glibenclamide (2.5 mg) tablets twice daily, separated by 14 days washout, 19 type 2 diabetic patients had ascending or descending three-step hype...

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Publication status:
Published

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Publisher copy:
10.1007/s00125-014-3399-1

Authors


Riefflin, A More by this author
Ayyagari, U More by this author
Manley, SE More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM, Biomedical Research Centre
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Publisher:
Springer Verlag
Journal:
Diabetologia
Volume:
58
Issue:
1
Pages:
43-49
Publication date:
2015-01-05
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
URN:
uuid:b3732c00-d5ff-4fd3-a4a9-33eafde2dfde
Source identifiers:
488956
Local pid:
pubs:488956

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