Comparative ontogeny, processing, and segmental distribution of the renal chloride channel, ClC-5.

Journal article

BACKGROUND: The renal chloride channel ClC-5, which is responsible for Dent's disease, is coexpressed with the vacuolar H+-ATPase in proximal tubules (PT) and alpha-type intercalated cells (IC) of the mature kidney. Neonatal cases of Dent's disease suggest that ClC-5 distribution must be acquired before birth. However, the ontogeny of ClC-5, and its processing and segmental distribution with respect to related proteins during nephrogenesis remain unknown. METHODS: Immunoblotting, real-time p...

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Authors: Jouret, F; Igarashi, T; Gofflot, F; Wilson, P; Karet, F

• Publication status: Published
• Journal: Kidney international
• Volume: 65
• Issue: 1
• Pages: 198-208
• Publication date: 2004-01-01
• DOI: 10.1111/j.1523-1755.2004.00360.x
• EISSN: 1523-1755
• ISSN: 0085-2538
• Language: English
• Keywords: RNA, Messenger; Glycosylation; Blood Group Antigens; Kidney Diseases; Humans; Proton-Translocating ATPases; Immunohistochemistry; Chloride Channels; Aquaporin 1; Antibodies, Monoclonal; Mice, Inbred Strains; Gene Expression Regulation, Developmental; Mice; Carbonic Anhydrases; Aquaporins; Kidney; Phenotype; Animals