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A single nucleotide polymorphism in the CD40 gene on chromosome 20q (GD-2) provides no evidence for susceptibility to Graves' disease in UK Caucasians.

Abstract:

OBJECTIVE: A genome-wide screen in Graves' disease (GD) has shown linkage to chromosome 20q, designated GD-2. The gene encoding CD40, which stimulates lymphocyte proliferation and differentiation, maps to this region, and a single nucleotide polymorphism (SNP) at position -1 of the Kozak sequence within the gene has been reported to be associated with GD. The aim of this study was to determine whether this SNP of the CD40 gene confers susceptibility to GD in UK Caucasians. DESIGN: A large ca...

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Authors


Heward, JM More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM
Carr-Smith, J More by this author
Franklyn, JA More by this author
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Journal:
Clinical endocrinology
Volume:
61
Issue:
2
Pages:
269-272
Publication date:
2004-08-05
DOI:
EISSN:
1365-2265
ISSN:
0300-0664
URN:
uuid:b3662e86-cf85-4501-8057-afde8d3d7f05
Source identifiers:
176397
Local pid:
pubs:176397

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