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IL-17 induces hyperalgesia via TNF-dependent neutrophil infiltration.

Abstract:

Interleukin-17 (IL-17) and tumour necrosis factor-α (TNF) are critical in the pathogenesis of arthritis but their relationship during inflammatory pain has received limited attention. We aimed to establish whether IL-17 can induce hyperalgesia in acute conditions, and investigated the role of TNF in mediating the pain response. Hyperalgesia was elicited in C57BL/6 mice by injection of recombinant IL-17, TNF or vehicle into the plantar tissue. Elevated pain was measured by the Hargreaves test ...

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Publication status:
Published

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Publisher copy:
10.1016/j.pain.2011.03.035

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Pain
Volume:
152
Issue:
8
Pages:
1838-1845
Publication date:
2011-08-01
DOI:
EISSN:
1872-6623
ISSN:
0304-3959
Source identifiers:
224041

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