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Complement factor H: using atomic resolution structure to illuminate disease mechanisms.

Abstract:

Complement Factor H has recently come to the fore with variant forms implicated in a range of serious disease states. This review aims to bring together recent data concerning the structure and biological activity of this molecule to highlight the way in which a molecular understanding of function may open novel therapeutic possibilities. In particular we examine the evidence for and against the hypothesis that sequence variations in factor H may predispose to disease if they perturb its abil...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Host title:
Advances in experimental medicine and biology
Volume:
632
Pages:
117-142
Publication date:
2008-01-01
Event location:
United States
DOI:
ISSN:
0065-2598
Source identifiers:
17651
ISBN:
9780387789514

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